解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Lung cancer is currently one of the most common malignant diseases and is responsible for substantial mortality worldwide. Compared with never smokers, former smokers remain at relatively high risk for lung cancer, accounting for approximately half of all newly diagnosed cases in the US. Screening offers former smoker...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-013-9517-x
更新日期:2014-02-01 00:00:00
abstract::Along with upper airway cough syndrome (formerly, postnasal drip syndrome) and eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), gastroesophageal reflux disease (GERD) is generally considered among the most common etiologies of chronic cough. Indeed, cough management guidelines published...
journal_title:Lung
pub_type:
doi:10.1007/s00408-013-9528-7
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, as current reports of its clinical features show. To determine CPFE's physiologic and radiologic features, we conducted quantitative assessment of computed tomography scans to compare with those of chronic obstructive pulmonary disease...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9513-1
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:In immunocompromised patients with pulmonary infiltrates, transbronchial lung biopsies (TBB) obtained by forceps has been shown to increase the diagnostic yield over simple bronchoalveolar lavage. Cryo-TBB is a novel modality for obtaining lung biopsies. We aimed to evaluate for the first time the efficacy a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9507-z
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the clinical and radiological features of patients with fungal infection mimicking thoracic malignancy and to establish a diagnostic approach for both clinicians and radiologists to avoid misdiagnosis. METHODS:In this retrospective study, we reviewed clinical and com...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-013-9506-0
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The aims of this study were to determine the incidence of tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease in patients who were treated with tumor necrosis factor (TNF) antagonists in South Korea and to evaluate their clinical characteristics. METHODS:We surveyed all patients (N = 509) w...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9481-5
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme 2 (ACE2), an ACE homolog, hydrolyzes angiotensin II and opposes its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanisms involved in the effect of ACE2 on PAH are still uncertain. In this study, we ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9470-8
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to compare the risk factors, clinical characteristics, and complications of respiratory distress syndrome (RDS) in infants delivered very preterm, late preterm, and term in order to help optimize the management of RDS in neonates. METHODS:A retrospective study was conducted on ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9475-3
更新日期:2013-08-01 00:00:00
abstract::Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease (COPD), which is characterized by progressive destruction of alveolar parenchyma with persistent inflammation of the small airways. Such destruction in the distal respiratory tract is irreversible and irreparable. All-trans-retinoic ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9438-0
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:This is a meta-analysis of the safety and efficacy of indacaterol in chronic obstructive pulmonary disease (COPD) with treatment duration of ≥12 weeks. METHODS:Randomized controlled trials (RCTs) reported in English (to September 30, 2012) were identified from PubMed, the Cochrane Library, Embase, websites,...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-012-9444-2
更新日期:2013-04-01 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9427-3
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Lymphangioleiomyomatosis (LAM) is a rare, progressive, frequently lethal cystic lung disease that almost exclusively affects women. Prognostic information in LAM has been limited by small numbers and heterogeneous study methodology. Early retrospective cohorts cited 5- and 10-year mortality of 40 and 80 %, resp...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9419-3
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Restoring the barrier integrity of the alveolar epithelium after injury is pivotal. In the current study, we evaluated the effects of surfactant, surfactant protein A (SP-A), transforming growth factor β (TGF-β), and analogues of SP-A on alveolar epithelial repair. Additionally, we assessed the influence of mic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9424-6
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Sildenafil was the only phosphodiesterase-5 inhibitor available for the treatment of pulmonary arterial hypertension (PAH) until the approval and availability of once-daily tadalafil. Since no direct comparative study is likely to be performed between these agents, we sought to evaluate the feasibility of tr...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9408-6
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:According to the National Family Health Survey, asthma is one of the leading diseases in India. In order to understand the complexity of asthma, the susceptibility genes need to be targeted for their association. Glutathione S-transferases play a major role in the detoxification of metabolites of oxidative s...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9385-9
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Mannitol is a novel osmotic indirect bronchial challenge agent used to aid asthma diagnosis and management and is thought to reflect underlying inflammatory processes in asthma. Our objective was to evaluate relationships between mannitol airway hyperresponsiveness (AHR) and other measures of airway inflamma...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9396-6
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Recent studies have shown the importance of Th17 cells in the development of allergic airway diseases. We examined Dermatophagoides pteronyssinus-induced changes in peripheral blood Th17 cells to establish the importance of these cells in late-phase allergic inflammation in patients with allergic rhinitis (A...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9411-y
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to perform a systematic review and meta-analysis of all randomized controlled trials that compared the efficacy of doublet versus single third-generation cytotoxic agent as first-line treatment for elderly patients with advanced non-small-cell lung cancer (NSCLC). METHODS:Several d...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-012-9399-3
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Exhaled nitric oxide (NO) levels have been reported to be lower in patients with cystic fibrosis (CF) than in controls; however the mechanism(s) responsible and the effect on pathogenesis are unclear. The objective of these studies was to determine if the low levels of gas phase NO (gNO) could be reproduced ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9395-7
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Several clinical trials of chemotherapy for non-small-cell lung cancer (NSCLC) have been conducted to date. However, these studies have not been effective at identifying category 1 recommended strategies for systemic chemotherapy according to the National Comprehensive Cancer Network clinical practice guidel...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-012-9379-7
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the p...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9390-z
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9371-2
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Patients with various chronic respiratory diseases have a higher incidence of gastroesophageal reflux disease (GERD)-related symptoms, but the mechanisms of the relationship between GERD symptoms and chronic obstructive pulmonary disease (COPD) remain unclear. The aim of the present study was to explore the ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9365-5
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Red cell distribution width (RDW) has been shown to be associated with adverse outcomes in left-sided heart failure, pulmonary hypertension, and in patients in the ICU. However, the role of RDW is unknown in patients with obstructive sleep apnea syndrome (OSAS), especially in OSAS patients with cardiovascula...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-012-9376-x
更新日期:2012-06-01 00:00:00
abstract:STUDY OBJECTIVES:The aim of this study was to determine if electrocardiographically synchronized, prospectively triggered multidetector row computed tomography (ECG-MDR-CT) angiography of the aorta can accurately predict the location of ectopic bronchial arteries in patients with cystic fibrosis (CF) with massive hemop...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9343-y
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Pulmonary endarterectomy is the treatment of choice in chronic thromboembolic pulmonary hypertension (CTEPH). Modern pulmonary vasoactive medication (like endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins) is used in patients with an inoperable disease and improved progn...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9350-z
更新日期:2012-04-01 00:00:00
abstract::The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-011-9348-6
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Pulmonary hypertension (PH) is a comorbidity associated with increased mortality in chronic obstructive pulmonary disease (COPD) patients. It is not known which clinical markers are predictive of PH in COPD. The goal of this study was to develop a clinical tool to identify patients who should be sent for ini...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9346-8
更新日期:2012-02-01 00:00:00
abstract:RATIONALE:The clinical characteristics and prognostic impact of radiographic patterns of patients with nontuberculous mycobacterial lung disease (NTM-LD) are rarely evaluated. DESIGN:Patients with NTM-LD from 2007 to 2009 in a single medical center in Taiwan were identified. Their radiographic patterns were reviewed a...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9321-4
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary exercise testing (CPET) is a safe and clinically useful method to assess functional capacity and to follow disease progression and the response to treatment in several clinical conditions. AIM:We set out to determine the relationship between outcome measures of CPET and high-resolution compu...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9316-1
更新日期:2011-10-01 00:00:00
abstract::Occupational exposure to oyster mushroom (Pleurotus ostreatus) has been associated with obstructive lung disease. Previously, we studied an extract of oyster mushroom (OME) and determined that it causes dose-dependent contractions of nonsensitized guinea pig trachea (GPT). We extend these studies to the investigation ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-011-9302-7
更新日期:2011-08-01 00:00:00
abstract::In critically ill patients, endotracheal intubation is associated with a high risk of complications, including severe hypoxemia and hypotension. The purpose of this review is to discuss the definitions, complications, airway assessment, and patient optimization with respect to these patients. In addition, we present d...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-011-9278-3
更新日期:2011-06-01 00:00:00
abstract::There is a lack of evidence about whether menopausal status influences the effect of smoking on lung function. This study examined the association between smoking and menopausal status and lung function independent of each other. Data were from a cohort of women attending the 21-year follow-up of the Mater University ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9269-9
更新日期:2011-02-01 00:00:00
abstract::An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb receptor occurs in two codominantly expressed allelic variants, NA1 and N...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9262-3
更新日期:2010-12-01 00:00:00
abstract::Simulation-based medical education has gained tremendous popularity over the past two decades. Driven by the patient safety movement, changes in the educational opportunities available to trainees and the rapidly evolving capabilities of computer technology, simulation-based medical education is now being used across ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-010-9260-5
更新日期:2010-12-01 00:00:00
abstract::Extrinsic allergic alveolitis (EAA) caused by inhaled organic environmental allergens can progress to a fibrotic end-stage lung disease. Neovascularization plays an important role in pathogenesis of pulmonary fibrosis. The aim of this study was to assess the effect of sera from EAA patients on the angiogenic capabilit...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9228-5
更新日期:2010-10-01 00:00:00
abstract::Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution. It plays important roles in various pathophysiological processes, including tissue remodeling, reproduction, lipid transport, complement regulation, and apoptosis. Clusterin appears to have two main isoforms that result from alternati...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-010-9248-1
更新日期:2010-10-01 00:00:00
abstract::In patients with congestive heart failure (CHF), a high prevalence of sleep-disordered breathing has been described. Cheyne-Stokes respiration (CSR) is present in up to 40% of patients with CHF. During the last decade, the medical treatment has been substantially improved. This study was designed to analyze the progno...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9208-9
更新日期:2010-08-01 00:00:00
abstract::A nodular lesion in the medial segment of right middle lobe was discovered on a chest radiograph for chronic cough in a 42-year-old Asian woman. A chest computed tomography (CT) scan subsequently showed a right middle lobe (RML) nodular lesion, which exhibited intense fluorodeoxyglucose uptake on positron emission tom...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9221-z
更新日期:2010-08-01 00:00:00
abstract::Bronchopleural (BPF) and alveolar-pleural (APF) fistulas are frequently encountered in clinical practice with persistent air leaks that can lead to significant morbidity, prolonged hospital stay, and potentially increased mortality. BPF and APF are commonly related to pulmonary resections. Other etiologies include min...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-009-9204-0
更新日期:2010-06-01 00:00:00